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PI3K-delta is known to play an important role in supporting cell proliferation and survival, cell differentiation, intercellular trafficking and immunity and is expressed in both normal and malignant B-cells. CK1-epsilon is a regulator of oncoprotein translation and has been implicated in the pathogenesis of cancer cells, including lymphoid malignancies. UKONIQ is indicated for the treatment of adult patients with relapsed or refractory marginal zone lymphoma MZL who have received at least one prior anti-CDbased regimen and for the treatment of adult patients with relapsed or refractory follicular lymphoma FL who have received at least three prior lines of systemic therapy.

These indications are approved under accelerated approval based on overall response rate.

Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial. Consider supportive care as appropriate. For patients with severe diarrhea Grade 3, i.

Monitor patients for new or worsening cutaneous reactions. Review all concomitant medications and discontinue any potentially contributing medications. Monitor at least weekly until resolved. Provide supportive care as appropriate. Advise pregnant women of the potential risk to a fetus. Advise females and males with female partners of reproductive potential to use effective contraception during treatment and for at least one month after the last dose.

Lactation: Because of the potential for serious adverse reactions from umbralisib in the breastfed child, advise women not to breastfeed during treatment with UKONIQ and for at least one month after the last dose. Please visit www. Accessed October 26, Cautionary StatementThis press release contains forward-looking statements within the meaning of the U. In addition to the risk factors identified from time to time in our reports filed with the U.

Further discussion about these and other risks and uncertainties can be found in our Annual Report on Form K for the fiscal year ended December 31, and in our other filings with the U. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.

This press release and prior releases are available at www.

The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. TGTX , Option 6. Arcosa, Inc. Organisers said that, despite its location opposite the Houses of Parliament. The Bayern Munich forward suffered the injury during Sunday's win over Andorra in Warsaw in which he scored two goals but had to leave the field in the 63rd minute. The local public health units are taking the lead in the protocols and governance of our industry. LJI is funded by the Government of Canada. Britain's competition watchdog said on Monday it had cleared Uber's takeover of UK tech firm Autocab, after its initial probe found the deal would not affect competition in the country's taxi booking and dispatch software market.

The Competition and Markets Authority CMA began its investigation into the deal in January for possible effects on supply of dispatch software - one of Autocab's key services - referral networks, and any potential merger of Autocab's customers. The growing military spending of many countries is fueling the development and procurement of advanced Space-based C4ISR systems.

Defense spending continued its increasing trend in despite the economic impact of the COVID pandemic. Countries are progressively adopting space-based systems for better situational awareness, secure and faster communication, and threat detection capabilities.

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On account of capability enhancement initiatives undertaken by the global military powerhouses, high demand for space-based C4ISR systems is expected to drive the market during the forecast period. Key Market TrendsAdvancements in Electronic Warfare TechnologiesThe nature of battles has changed drastically with the advent of technology. For various military requirements, including communication, the defense agencies around the world require space capability to meet the demand for more operationally responsive forces.

Electronic warfare has gained tremendous significance over the past decade.

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Electronic warfare EW is traditionally divided into an electronic attack, electronic protection, and electronic warfare support. But in recent years, a fourth element has been added, i. Global defense forces deploy space-based C4ISR systems to monitor and analyze points of interest located in hostile territory. Countries, such as the United States, Russia, and China, have diverted their efforts toward the development of sophisticated and powerful C4ISR systems that can penetrate the defenses of hostile adversaries to obtain mission-critical information.

Russia is aggressively advancing in this segment to conduct electronic warfare against foreign satellites. At the center of this effort is the development of a variety of mobile ground-based systems to interfere with the operations of both communications and radar reconnaissance satellites.

Work is also in progress to perform electronic warfare from space using nuclear-powered satellites. With space-based communication, reconnaissance, and navigation systems playing an ever-increasing role in ensuring the success of military operations, satellites have become a key target for EW systems. Major defense spending countries are consistently investing on EW modernization and field a variety of new EW systems to augment the capabilities of all service branches. Some EW systems are aimed at jamming and spoofing communications user terminals and GPS receivers within a local area while some other jammers are designed to interfere with the satellites themselves, affecting services for all users in the satellite reception area.

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The agency has been in talks with different companies to procure the said technology since and issued the RFI in January The agency is looking for a system that can be enhanced to play an offensive role in the future. Thus, the increasing adoption of electronic warfare is expected to drive the demand for sophisticated C4ISR systems and fuel the growth of the market in focus during the forecast period. The United States has invested its vast technological prowess toward the indigenous development of several weapon systems to foster its military prowess over all dominions.

The United States has deployed more space assets than any other country in the world, and it is heavily reliant on the deployed space framework to support and enhance its war-fighting capability. The US SOCOM envisions network-centric warfare as a vital domain for the expansion of joint operational programs by the defense forces. On this note, the United States is launching several satellites every year to extend its military communication capabilities.

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The NROL is a geosynchronous signals intelligence SIGINT satellite weighing more than 5 tons and is outfitted with a huge parabolic antenna, which unfolds to a diameter of more than meters in space. The AEHF-5 provides jam-proof communications, including real-time video streaming between the control and the deployed forces. In May , the US launched the Harbinger satellite to demonstrate synthetic aperture radar imaging capability and high-bandwidth downlink capabilities in a small satellite.

Several such launches are scheduled during the forecast period, therefore driving the North American segment of the market in focus. FDA previously granted Fast Track designation to the combination of ublituximab and umbralisib U2 for the treatment of adult patients with CLL and orphan drug designation for ublituximab in combination with umbralisib for the treatment of CLL.

Michael S. The FDA has previously granted the U2 combination both fast track designation as well as orphan drug designation for patients with CLL and we look forward to continuing to work closely with the FDA with the goal of bringing this novel treatment regimen to patients as quickly as possible. A prespecified interim analysis was conducted to assess the contribution of ublituximab and UKONIQ in the U2 combination arm and allowed for the termination of the single agent arms.

Accordingly, the UNITY-CLL Phase 3 trial continued enrollment in a ratio into the two combination arms: the investigational arm of U2 and the control arm of obinutuzumab plus chlorambucil. The primary endpoint for this study was superior progression-free survival PFS for the U2 combination compared to the control arm to support the submission of the U2 combination in CLL.

It is estimated there will be more than 20, new cases of CLL diagnosed in the United States in and approximately 45, new cases globally in Filling an unmet medical need is defined as providing a therapy where none exists or providing a therapy that may be potentially better than available therapy. A drug that receives Fast Track designation is eligible for more frequent interactions with the FDA, priority review if relevant criteria are met, and rolling submission of the Biologics License Application or New Drug Application.

Orphan drug designation provides certain incentives which may include tax credits towards the cost of clinical trials and prescription drug user fee waivers. If a product that has orphan drug designation subsequently receives the first FDA approval for the disease for which it has such designation, the product is entitled to orphan product exclusivity. TG Therapeutics is a fully-integrated, commercial stage biopharmaceutical company focused on the acquisition, development and commercialization of novel treatments for B-cell malignancies and autoimmune diseases.

In addition to an active research pipeline including five investigational medicines across these therapeutic areas, UKONIQTM umbralisib received accelerated approval from the U. Currently, the Company has programs in Phase 3 development for the treatment of patients with relapsing forms of multiple sclerosis RMS and for the treatment of patients with chronic lymphocytic leukemia CLL as well as several investigational medicines in Phase 1 clinical development. For more information, visit www. PI3K-delta is known to play an important role in supporting cell proliferation and survival, cell differentiation, intercellular trafficking and immunity and is expressed in both normal and malignant B-cells.

CK1-epsilon is a regulator of oncoprotein translation and has been implicated in the pathogenesis of cancer cells, including lymphoid malignancies. UKONIQ is indicated for the treatment of adult patients with relapsed or refractory marginal zone lymphoma MZL who have received at least one prior anti-CDbased regimen and for the treatment of adult patients with relapsed or refractory follicular lymphoma FL who have received at least three prior lines of systemic therapy. These indications are approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Consider supportive care as appropriate. For patients with severe diarrhea Grade 3, i. Monitor patients for new or worsening cutaneous reactions. Review all concomitant medications and discontinue any potentially contributing medications. Monitor at least weekly until resolved. Provide supportive care as appropriate. Advise pregnant women of the potential risk to a fetus.

Advise females and males with female partners of reproductive potential to use effective contraception during treatment and for at least one month after the last dose. Lactation: Because of the potential for serious adverse reactions from umbralisib in the breastfed child, advise women not to breastfeed during treatment with UKONIQ and for at least one month after the last dose. Please visit www. Accessed October 26, Cautionary StatementThis press release contains forward-looking statements within the meaning of the U. In addition to the risk factors identified from time to time in our reports filed with the U.

Further discussion about these and other risks and uncertainties can be found in our Annual Report on Form K for the fiscal year ended December 31, and in our other filings with the U. Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.

This press release and prior releases are available at www. The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. TGTX , Option 6. The Bayern Munich forward suffered the injury during Sunday's win over Andorra in Warsaw in which he scored two goals but had to leave the field in the 63rd minute.

The local public health units are taking the lead in the protocols and governance of our industry. LJI is funded by the Government of Canada. Britain's competition watchdog said on Monday it had cleared Uber's takeover of UK tech firm Autocab, after its initial probe found the deal would not affect competition in the country's taxi booking and dispatch software market. The Competition and Markets Authority CMA began its investigation into the deal in January for possible effects on supply of dispatch software - one of Autocab's key services - referral networks, and any potential merger of Autocab's customers.